/* ═══════════════════════════════════════════════════════
   PIPELINEEVIDENCE — Design System v2
   Clinical precision meets editorial authority
   ═══════════════════════════════════════════════════════ */

@import url('https://fonts.googleapis.com/css2?family=Outfit:wght@300;400;500;600;700;800;900&family=Source+Serif+4:ital,opsz,wght@0,8..60,400;0,8..60,600;0,8..60,700;0,8..60,800;1,8..60,400&family=IBM+Plex+Mono:wght@400;500;600&display=swap');

*, *::before, *::after { margin: 0; padding: 0; box-sizing: border-box; }

:root {
    /* Core palette — deep navy with electric accents */
    --bg-primary: #060b18;
    --bg-secondary: #0c1425;
    --bg-card: #111c32;
    --bg-card-hover: #162340;
    --bg-elevated: #0f1a2e;
    --bg-glass: rgba(11, 20, 40, 0.75);

    /* Borders */
    --border-primary: #1a2d4d;
    --border-subtle: rgba(100, 140, 200, 0.08);
    --border-glow: rgba(56, 152, 255, 0.2);

    /* Typography colors */
    --text-primary: #edf2f7;
    --text-secondary: #8b9cc0;
    --text-muted: #5a6d8a;

    /* Accent system */
    --accent: #3898ff;
    --accent-light: #5eabff;
    --accent-soft: #5eabff;
    --accent-glow: rgba(56, 152, 255, 0.12);
    --accent-glow-strong: rgba(56, 152, 255, 0.25);
    --cyan: #00d4ff;
    --emerald: #00e6a0;
    --amber: #ffb800;
    --rose: #ff5277;
    --violet: #a78bfa;

    /* Gradients */
    --gradient-hero: linear-gradient(135deg, #3898ff 0%, #00d4ff 50%, #00e6a0 100%);
    --gradient-card: linear-gradient(145deg, rgba(56,152,255,0.06) 0%, rgba(0,212,255,0.03) 100%);
    --gradient-text: linear-gradient(135deg, #edf2f7 0%, #8b9cc0 100%);

    /* Typography */
    --font-body: 'Outfit', -apple-system, BlinkMacSystemFont, sans-serif;
    --font-display: 'Source Serif 4', Georgia, 'Times New Roman', serif;
    --font-mono: 'IBM Plex Mono', 'Fira Code', monospace;

    /* Spacing scale */
    --space-xs: 0.25rem;
    --space-sm: 0.5rem;
    --space-md: 1rem;
    --space-lg: 1.5rem;
    --space-xl: 2.5rem;
    --space-2xl: 4rem;
    --space-3xl: 6rem;

    /* Radius */
    --radius-sm: 6px;
    --radius-md: 10px;
    --radius-lg: 16px;
    --radius-xl: 24px;

    /* Shadows */
    --shadow-card: 0 4px 20px rgba(0,0,0,0.25), 0 1px 3px rgba(0,0,0,0.15);
    --shadow-hover: 0 12px 40px rgba(0,0,0,0.35), 0 0 30px var(--accent-glow);
    --shadow-glow: 0 0 40px var(--accent-glow), 0 0 80px rgba(56,152,255,0.04);

    /* Transitions */
    --ease-out: cubic-bezier(0.16, 1, 0.3, 1);
    --ease-spring: cubic-bezier(0.34, 1.56, 0.64, 1);
    --transition: 0.35s var(--ease-out);
    --transition-fast: 0.2s var(--ease-out);
}

/* ═══ BASE ═══ */
body {
    font-family: var(--font-body);
    background: var(--bg-primary);
    color: var(--text-primary);
    line-height: 1.7;
    font-size: 16px;
    -webkit-font-smoothing: antialiased;
    -moz-osx-font-smoothing: grayscale;
    overflow-x: hidden;
}

/* Atmospheric background */
body::before {
    content: '';
    position: fixed;
    inset: 0;
    background:
        radial-gradient(ellipse 100% 70% at 20% -10%, rgba(56,152,255,0.05), transparent 60%),
        radial-gradient(ellipse 80% 50% at 80% 110%, rgba(0,212,255,0.03), transparent 50%),
        radial-gradient(circle at 50% 50%, rgba(0,230,160,0.015), transparent 70%);
    pointer-events: none;
    z-index: 0;
}

/* Subtle noise texture */
body::after {
    content: '';
    position: fixed;
    inset: 0;
    opacity: 0.015;
    background-image: url("data:image/svg+xml,%3Csvg viewBox='0 0 256 256' xmlns='http://www.w3.org/2000/svg'%3E%3Cfilter id='n'%3E%3CfeTurbulence type='fractalNoise' baseFrequency='0.85' numOctaves='4' stitchTiles='stitch'/%3E%3C/filter%3E%3Crect width='100%25' height='100%25' filter='url(%23n)'/%3E%3C/svg%3E");
    pointer-events: none;
    z-index: 0;
}

a { color: var(--accent-soft); text-decoration: none; transition: color var(--transition-fast); }
a:hover { color: var(--cyan); }

::selection { background: rgba(56,152,255,0.25); color: #fff; }

/* ═══ HEADER ═══ */
.pe-header {
    position: sticky;
    top: 0;
    z-index: 1000;
    background: rgba(6, 11, 24, 0.8);
    backdrop-filter: blur(24px) saturate(1.4);
    -webkit-backdrop-filter: blur(24px) saturate(1.4);
    border-bottom: 1px solid var(--border-subtle);
    transition: box-shadow var(--transition);
}
.pe-header.scrolled { box-shadow: 0 4px 30px rgba(0,0,0,0.5); }
.pe-header-inner {
    max-width: 1400px;
    margin: 0 auto;
    padding: 0 2rem;
    height: 64px;
    display: flex;
    justify-content: space-between;
    align-items: center;
}
.pe-logo {
    font-family: var(--font-display);
    font-size: 1.3rem;
    font-weight: 700;
    text-decoration: none;
    letter-spacing: -0.01em;
}
.pe-logo .mark { color: var(--accent); }
.pe-logo .word { color: var(--text-primary); }
.pe-nav { display: flex; gap: 0.25rem; align-items: center; }
.pe-nav a {
    font-size: 0.82rem;
    font-weight: 500;
    color: var(--text-secondary);
    padding: 0.4rem 0.75rem;
    border-radius: var(--radius-sm);
    transition: all var(--transition-fast);
    text-decoration: none;
}
.pe-nav a:hover { color: var(--text-primary); background: var(--accent-glow); }
.pe-nav a.active { color: var(--accent-soft); }

/* Mobile nav */
@media (max-width: 768px) {
    .pe-nav { gap: 0; }
    .pe-nav a { padding: 0.4rem 0.5rem; font-size: 0.75rem; }
    .pe-header-inner { padding: 0 1rem; }
}

/* ═══ HERO ═══ */
.pe-hero {
    position: relative;
    padding: var(--space-3xl) 2rem;
    text-align: center;
    overflow: hidden;
}
.pe-hero::before {
    content: '';
    position: absolute;
    top: -50%;
    left: 50%;
    transform: translateX(-50%);
    width: 800px;
    height: 800px;
    background: radial-gradient(circle, rgba(56,152,255,0.08) 0%, transparent 70%);
    pointer-events: none;
}
.pe-hero-badge {
    display: inline-flex;
    align-items: center;
    gap: 0.5rem;
    font-size: 0.75rem;
    font-weight: 600;
    color: var(--accent-soft);
    background: rgba(56,152,255,0.08);
    border: 1px solid rgba(56,152,255,0.15);
    padding: 0.35rem 1rem;
    border-radius: 100px;
    text-transform: uppercase;
    letter-spacing: 0.08em;
    margin-bottom: var(--space-lg);
    animation: fadeInDown 0.8s var(--ease-out) both;
}
.pe-hero h1 {
    font-family: var(--font-display);
    font-size: clamp(2.5rem, 5vw, 4rem);
    font-weight: 800;
    line-height: 1.1;
    letter-spacing: -0.02em;
    color: var(--text-primary);
    max-width: 900px;
    margin: 0 auto var(--space-lg);
    animation: fadeInUp 0.8s 0.15s var(--ease-out) both;
}
.pe-hero h1 .gradient-text {
    background: var(--gradient-hero);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}
.pe-hero .subtitle {
    font-size: 1.15rem;
    color: var(--text-secondary);
    max-width: 640px;
    margin: 0 auto var(--space-xl);
    line-height: 1.7;
    font-weight: 400;
    animation: fadeInUp 0.8s 0.3s var(--ease-out) both;
}

/* ═══ STAT STRIP ═══ */
.pe-stats {
    display: flex;
    justify-content: center;
    gap: var(--space-2xl);
    flex-wrap: wrap;
    padding: var(--space-lg) 0;
    animation: fadeInUp 0.8s 0.45s var(--ease-out) both;
}
.pe-stat {
    text-align: center;
}
.pe-stat-value {
    font-family: var(--font-display);
    font-size: 2.5rem;
    font-weight: 800;
    line-height: 1;
    background: var(--gradient-hero);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}
.pe-stat-label {
    font-size: 0.78rem;
    font-weight: 500;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.1em;
    margin-top: 0.25rem;
}

/* ═══ SECTION ═══ */
.pe-section {
    max-width: 1400px;
    margin: 0 auto;
    padding: var(--space-3xl) 2rem;
    position: relative;
    z-index: 1;
}
.pe-section-header {
    margin-bottom: var(--space-xl);
}
.pe-section-header .overline {
    font-size: 0.7rem;
    font-weight: 700;
    color: var(--accent);
    text-transform: uppercase;
    letter-spacing: 0.15em;
    margin-bottom: 0.5rem;
}
.pe-section-header h2 {
    font-family: var(--font-display);
    font-size: 2rem;
    font-weight: 700;
    color: var(--text-primary);
    letter-spacing: -0.01em;
    line-height: 1.2;
}
.pe-section-header p {
    color: var(--text-secondary);
    font-size: 1rem;
    max-width: 600px;
    margin-top: 0.75rem;
    line-height: 1.7;
}

/* ═══ TUMOR GRID ═══ */
.pe-tumor-grid {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(220px, 1fr));
    gap: 0.75rem;
}
.pe-tumor-card {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    padding: 0.875rem 1rem;
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    text-decoration: none;
    transition: all var(--transition);
    position: relative;
    overflow: hidden;
}
.pe-tumor-card::before {
    content: '';
    position: absolute;
    left: 0; top: 0; bottom: 0;
    width: 3px;
    background: var(--accent);
    transform: scaleY(0);
    transition: transform var(--transition);
}
.pe-tumor-card:hover {
    background: var(--bg-card-hover);
    border-color: var(--border-glow);
    transform: translateY(-2px);
    box-shadow: var(--shadow-hover);
}
.pe-tumor-card:hover::before { transform: scaleY(1); }
.pe-tumor-card .name {
    font-size: 0.88rem;
    font-weight: 500;
    color: var(--text-primary);
}
.pe-tumor-card .count {
    font-size: 0.72rem;
    font-weight: 600;
    color: var(--accent-soft);
    background: var(--accent-glow);
    padding: 0.15rem 0.5rem;
    border-radius: 100px;
    margin-left: auto;
    white-space: nowrap;
}

/* ═══ FEATURE CARDS ═══ */
.pe-features {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 1.25rem;
}
.pe-feature {
    padding: 2rem;
    background: var(--gradient-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-lg);
    transition: all var(--transition);
}
.pe-feature:hover {
    border-color: var(--border-glow);
    box-shadow: var(--shadow-hover);
    transform: translateY(-3px);
}
.pe-feature-icon {
    width: 48px;
    height: 48px;
    border-radius: 12px;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    margin-bottom: 1.25rem;
}
.pe-feature h3 {
    font-family: var(--font-body);
    font-size: 1.1rem;
    font-weight: 600;
    color: var(--text-primary);
    margin-bottom: 0.5rem;
}
.pe-feature p {
    color: var(--text-secondary);
    font-size: 0.9rem;
    line-height: 1.7;
}

/* ═══ CTA BANNER ═══ */
.pe-cta {
    background: linear-gradient(135deg, rgba(56,152,255,0.08) 0%, rgba(0,230,160,0.05) 100%);
    border: 1px solid rgba(56,152,255,0.12);
    border-radius: var(--radius-xl);
    padding: var(--space-2xl);
    text-align: center;
    position: relative;
    overflow: hidden;
}
.pe-cta::before {
    content: '';
    position: absolute;
    inset: 0;
    background: radial-gradient(circle at 30% 50%, rgba(56,152,255,0.06), transparent 60%);
    pointer-events: none;
}
.pe-cta h2 {
    font-family: var(--font-display);
    font-size: 1.8rem;
    font-weight: 700;
    color: var(--text-primary);
    margin-bottom: 0.75rem;
    position: relative;
}
.pe-cta p {
    color: var(--text-secondary);
    font-size: 1rem;
    max-width: 500px;
    margin: 0 auto var(--space-lg);
    position: relative;
}
.pe-btn {
    display: inline-flex;
    align-items: center;
    gap: 0.5rem;
    padding: 0.75rem 1.75rem;
    font-family: var(--font-body);
    font-size: 0.9rem;
    font-weight: 600;
    color: #fff;
    background: var(--accent);
    border: none;
    border-radius: 100px;
    text-decoration: none;
    cursor: pointer;
    transition: all var(--transition);
    position: relative;
    overflow: hidden;
}
.pe-btn:hover {
    background: var(--accent-soft);
    transform: translateY(-1px);
    box-shadow: 0 8px 25px rgba(56,152,255,0.3);
    color: #fff;
}
.pe-btn-ghost {
    background: transparent;
    border: 1px solid var(--border-glow);
    color: var(--accent-soft);
}
.pe-btn-ghost:hover {
    background: var(--accent-glow);
    color: var(--text-primary);
    box-shadow: none;
}

/* ═══ FOOTER ═══ */
.pe-footer {
    max-width: 1400px;
    margin: 0 auto;
    padding: var(--space-2xl) 2rem;
    border-top: 1px solid var(--border-subtle);
    position: relative;
    z-index: 1;
}
.pe-footer-grid {
    display: grid;
    grid-template-columns: 2fr 1fr 1fr 1fr;
    gap: 2rem;
}
@media (max-width: 768px) {
    .pe-footer-grid { grid-template-columns: 1fr 1fr; }
}
@media (max-width: 480px) {
    .pe-footer-grid { grid-template-columns: 1fr; }
}
.pe-footer-brand {
    font-family: var(--font-display);
    font-size: 1.1rem;
    font-weight: 700;
    margin-bottom: 0.75rem;
}
.pe-footer-brand .mark { color: var(--accent); }
.pe-footer h4 {
    font-size: 0.72rem;
    font-weight: 700;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.12em;
    margin-bottom: 0.75rem;
}
.pe-footer a {
    display: block;
    font-size: 0.85rem;
    color: var(--text-secondary);
    padding: 0.2rem 0;
    text-decoration: none;
    transition: color var(--transition-fast);
}
.pe-footer a:hover { color: var(--text-primary); }
.pe-footer-bottom {
    margin-top: var(--space-xl);
    padding-top: var(--space-lg);
    border-top: 1px solid var(--border-subtle);
    text-align: center;
    font-size: 0.75rem;
    color: var(--text-muted);
}

/* ═══ ANIMATIONS ═══ */
@keyframes fadeInUp {
    from { opacity: 0; transform: translateY(20px); }
    to { opacity: 1; transform: translateY(0); }
}
@keyframes fadeInDown {
    from { opacity: 0; transform: translateY(-10px); }
    to { opacity: 1; transform: translateY(0); }
}
@keyframes fadeIn {
    from { opacity: 0; }
    to { opacity: 1; }
}
@keyframes slideInLeft {
    from { opacity: 0; transform: translateX(-20px); }
    to { opacity: 1; transform: translateX(0); }
}
@keyframes pulse {
    0%, 100% { opacity: 1; }
    50% { opacity: 0.5; }
}

/* Scroll-triggered animations */
.reveal {
    opacity: 0;
    transform: translateY(24px);
    transition: opacity 0.7s var(--ease-out), transform 0.7s var(--ease-out);
}
.reveal.visible {
    opacity: 1;
    transform: translateY(0);
}

/* ═══ CONTENT CARDS (articles, glossary) ═══ */
.pe-content-card {
    display: block;
    padding: 1.5rem;
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-lg);
    text-decoration: none;
    transition: all var(--transition);
}
.pe-content-card:hover {
    border-color: var(--border-glow);
    transform: translateY(-2px);
    box-shadow: var(--shadow-hover);
}

/* ═══ EDITORIAL TEXT (tumor pages) ═══ */
.pe-prose p {
    color: var(--text-secondary);
    line-height: 1.85;
    font-size: 0.95rem;
    margin-bottom: 1rem;
}
.pe-prose h3 {
    font-family: var(--font-display);
    font-size: 1.2rem;
    color: var(--accent-soft);
    margin-bottom: 0.75rem;
    padding-bottom: 0.4rem;
    border-bottom: 1px solid rgba(56,152,255,0.12);
}

/* ═══ SEARCH / FILTER BAR ═══ */
.pe-search {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    padding: 0.6rem 1rem;
    background: var(--bg-elevated);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-lg);
    transition: border-color var(--transition-fast);
}
.pe-search:focus-within { border-color: var(--accent); box-shadow: 0 0 0 3px var(--accent-glow); }
.pe-search input {
    flex: 1;
    background: none;
    border: none;
    outline: none;
    color: var(--text-primary);
    font-family: var(--font-body);
    font-size: 0.9rem;
}
.pe-search input::placeholder { color: var(--text-muted); }

/* ═══ BADGE / TAG ═══ */
.pe-tag {
    display: inline-flex;
    align-items: center;
    font-size: 0.7rem;
    font-weight: 600;
    padding: 0.2rem 0.6rem;
    border-radius: 100px;
    text-transform: uppercase;
    letter-spacing: 0.06em;
}
.pe-tag-blue { color: var(--accent-soft); background: var(--accent-glow); border: 1px solid rgba(56,152,255,0.15); }
.pe-tag-green { color: var(--emerald); background: rgba(0,230,160,0.08); border: 1px solid rgba(0,230,160,0.15); }
.pe-tag-amber { color: var(--amber); background: rgba(255,184,0,0.08); border: 1px solid rgba(255,184,0,0.15); }
.pe-tag-rose { color: var(--rose); background: rgba(255,82,119,0.08); border: 1px solid rgba(255,82,119,0.15); }

/* ═══ DISCLAIMER BANNER ═══ */
.pe-disclaimer-banner {
    padding: 1rem 1.5rem;
    background: rgba(255,82,119,0.04);
    border: 1px solid rgba(255,82,119,0.12);
    border-radius: var(--radius-md);
    font-size: 0.85rem;
    color: var(--text-secondary);
    line-height: 1.6;
}
.pe-disclaimer-banner strong { color: var(--rose); }

/* ═══ RESPONSIVE ═══ */
@media (max-width: 640px) {
    .pe-hero { padding: var(--space-2xl) 1rem; }
    .pe-hero h1 { font-size: 2rem; }
    .pe-stats { gap: var(--space-lg); }
    .pe-stat-value { font-size: 1.8rem; }
    .pe-section { padding: var(--space-2xl) 1rem; }
    .pe-tumor-grid { grid-template-columns: 1fr; }
    .pe-features { grid-template-columns: 1fr; }
}

/* ═══════════════════════════════════════════════════════
   TUMOR PAGE STYLES — Hero, Stats, Drug Cards, Navigation
   ═══════════════════════════════════════════════════════ */

/* Tumor Hero */
.tumor-hero {
    position: relative;
    padding: var(--space-3xl) 2rem var(--space-2xl);
    max-width: 1400px;
    margin: 0 auto;
    overflow: hidden;
}
.tumor-hero::before {
    content: '';
    position: absolute;
    top: -100px;
    right: -100px;
    width: 500px;
    height: 500px;
    background: radial-gradient(circle, var(--accent-glow-strong) 0%, transparent 70%);
    opacity: 0.4;
    pointer-events: none;
}
.tumor-hero-inner {
    display: grid;
    grid-template-columns: 1fr auto;
    gap: var(--space-xl);
    align-items: center;
    position: relative;
    z-index: 1;
}
.tumor-hero h1 {
    font-family: var(--font-display);
    font-size: 2.75rem;
    font-weight: 800;
    color: var(--text-primary);
    line-height: 1.15;
    letter-spacing: -0.02em;
    margin-bottom: var(--space-md);
}
.tumor-hero h1 .gradient-text {
    background: var(--gradient-hero);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}
.tumor-hero .hero-subtitle {
    font-size: 1.05rem;
    color: var(--text-secondary);
    line-height: 1.7;
    max-width: 720px;
}
.tumor-icon-ring {
    width: 160px;
    height: 160px;
    border-radius: 50%;
    background: linear-gradient(135deg, rgba(56,152,255,0.08), rgba(0,212,255,0.06));
    border: 2px solid var(--border-glow);
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 4.5rem;
    box-shadow: var(--shadow-glow);
    flex-shrink: 0;
    animation: iconPulse 4s ease-in-out infinite;
}
@keyframes iconPulse {
    0%, 100% { box-shadow: var(--shadow-glow); }
    50% { box-shadow: 0 0 60px var(--accent-glow-strong), 0 0 100px rgba(56,152,255,0.06); }
}

/* Stat Grid */
.tumor-stats {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: var(--space-lg);
    margin-top: var(--space-xl);
    position: relative;
    z-index: 1;
}
.tumor-stat {
    background: var(--gradient-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    padding: var(--space-lg) var(--space-md);
    text-align: center;
    transition: var(--transition);
    position: relative;
    overflow: hidden;
}
.tumor-stat::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 3px;
    background: var(--gradient-hero);
    opacity: 0;
    transition: var(--transition);
}
.tumor-stat:hover { border-color: var(--border-glow); transform: translateY(-2px); }
.tumor-stat:hover::before { opacity: 1; }
.tumor-stat-value {
    font-family: var(--font-mono);
    font-size: 2rem;
    font-weight: 700;
    background: var(--gradient-hero);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    line-height: 1.2;
}
.tumor-stat-label {
    font-size: 0.72rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.12em;
    margin-top: var(--space-xs);
    font-weight: 600;
}

/* Legacy hero/stat compatibility */
.hero {
    position: relative;
    padding: var(--space-3xl) 2rem var(--space-xl);
    max-width: 1400px;
    margin: 0 auto;
}
.hero h1 {
    font-family: var(--font-display);
    font-size: 2.75rem;
    font-weight: 800;
    color: var(--text-primary);
    line-height: 1.15;
    letter-spacing: -0.02em;
    margin-bottom: var(--space-md);
}
.hero h1 span {
    background: var(--gradient-hero);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}
.hero-content {
    max-width: 1400px;
    margin: 0 auto;
}
.hero-stats {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: var(--space-lg);
    margin-top: var(--space-xl);
}
.stat-card {
    background: var(--gradient-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    padding: var(--space-lg) var(--space-md);
    text-align: center;
    transition: var(--transition);
}
.stat-card:hover { border-color: var(--border-glow); transform: translateY(-2px); }
.stat-value, .stat-number {
    font-family: var(--font-mono);
    font-size: 2rem;
    font-weight: 700;
    background: var(--gradient-hero);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    line-height: 1.2;
}
.stat-label {
    font-size: 0.72rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.12em;
    margin-top: var(--space-xs);
    font-weight: 600;
}

/* Drug Cards */
.drug-card {
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    padding: var(--space-lg);
    margin-bottom: var(--space-lg);
    transition: var(--transition);
    position: relative;
    overflow: hidden;
}
.drug-card::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    width: 4px;
    height: 100%;
    background: var(--gradient-hero);
    opacity: 0.5;
}
.drug-card:hover {
    border-color: var(--border-glow);
    box-shadow: var(--shadow-card);
    transform: translateY(-1px);
}
.drug-name {
    font-family: var(--font-display);
    font-size: 1.35rem;
    font-weight: 700;
    color: var(--text-primary);
    margin-bottom: 0.2rem;
}
.drug-generic {
    font-size: 0.9rem;
    color: var(--accent-soft);
    font-style: italic;
    margin-bottom: var(--space-sm);
}
.drug-header {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    margin-bottom: var(--space-md);
}
.drug-section {
    padding: var(--space-sm) 0;
    border-top: 1px solid var(--border-subtle);
}
.drug-section-title {
    font-size: 0.72rem;
    font-weight: 700;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.1em;
    margin-bottom: 0.35rem;
}
.badge-approved {
    display: inline-block;
    background: rgba(0,230,160,0.08);
    color: var(--emerald);
    padding: 0.3rem 0.75rem;
    border-radius: 20px;
    font-size: 0.78rem;
    font-weight: 600;
    border: 1px solid rgba(0,230,160,0.15);
    margin-bottom: var(--space-sm);
}
.trial-link {
    color: var(--accent-light, var(--accent-soft));
    text-decoration: none;
    font-weight: 600;
    transition: var(--transition-fast);
}
.trial-link:hover { color: var(--cyan); }

/* All Therapies Page */
.stats-bar {
    display: flex;
    justify-content: center;
    gap: var(--space-xl);
    padding: var(--space-lg) 0;
    margin-bottom: var(--space-lg);
}
.stat-item { text-align: center; }
.stat-item .stat-number {
    font-family: var(--font-mono);
    font-size: 2.2rem;
    font-weight: 700;
    background: var(--gradient-hero);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}
.stat-item .stat-label {
    font-size: 0.75rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.1em;
    font-weight: 600;
}
.container {
    max-width: 1400px;
    margin: 0 auto;
    padding: 0 2rem;
}

/* Filter Bar */
.filter-bar {
    background: var(--bg-secondary);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    padding: var(--space-lg);
    margin-bottom: var(--space-xl);
}
.filter-row {
    display: flex;
    gap: var(--space-md);
    align-items: flex-end;
    flex-wrap: wrap;
}
.filter-group {
    flex: 1;
    min-width: 180px;
}
.filter-group label {
    display: block;
    font-size: 0.72rem;
    font-weight: 700;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.1em;
    margin-bottom: var(--space-xs);
}
.filter-group input,
.filter-group select {
    width: 100%;
    padding: 0.6rem 0.85rem;
    background: var(--bg-card);
    border: 1px solid var(--border-primary);
    border-radius: var(--radius-sm);
    color: var(--text-primary);
    font-family: var(--font-body);
    font-size: 0.88rem;
    transition: var(--transition-fast);
}
.filter-group input:focus,
.filter-group select:focus {
    outline: none;
    border-color: var(--accent);
    box-shadow: 0 0 0 3px var(--accent-glow);
}
.clear-btn {
    padding: 0.6rem 1.25rem;
    background: transparent;
    border: 1px solid var(--border-primary);
    border-radius: var(--radius-sm);
    color: var(--text-secondary);
    font-family: var(--font-body);
    font-size: 0.85rem;
    cursor: pointer;
    transition: var(--transition-fast);
    white-space: nowrap;
}
.clear-btn:hover {
    border-color: var(--accent);
    color: var(--accent);
}

/* Table */
.table-wrapper {
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    overflow: hidden;
}
.table-wrapper table {
    width: 100%;
    border-collapse: collapse;
}
.table-wrapper thead {
    background: var(--bg-secondary);
}
.table-wrapper th {
    padding: 0.85rem 1rem;
    text-align: left;
    font-size: 0.72rem;
    font-weight: 700;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.1em;
    border-bottom: 2px solid var(--border-primary);
    cursor: pointer;
    user-select: none;
    transition: var(--transition-fast);
}
.table-wrapper th:hover { color: var(--accent); }
.table-wrapper td {
    padding: 0.875rem 1rem;
    border-bottom: 1px solid var(--border-subtle);
    font-size: 0.9rem;
    color: var(--text-primary);
    vertical-align: top;
}
.table-wrapper tbody tr {
    transition: var(--transition-fast);
}
.table-wrapper tbody tr:hover {
    background: rgba(56,152,255,0.04);
}

/* Tumor Grid Cards for All Therapies hub */
.tumor-grid-hub {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(220px, 1fr));
    gap: var(--space-lg);
    margin-top: var(--space-xl);
}
.tumor-card-hub {
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-md);
    padding: var(--space-lg) var(--space-md);
    text-align: center;
    text-decoration: none;
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--space-sm);
    transition: var(--transition);
    position: relative;
    overflow: hidden;
}
.tumor-card-hub::after {
    content: '';
    position: absolute;
    bottom: 0;
    left: 0;
    right: 0;
    height: 3px;
    background: var(--gradient-hero);
    opacity: 0;
    transition: var(--transition);
}
.tumor-card-hub:hover {
    border-color: var(--border-glow);
    transform: translateY(-4px);
    box-shadow: var(--shadow-hover);
}
.tumor-card-hub:hover::after { opacity: 1; }
.tumor-card-hub .tc-icon {
    font-size: 2.5rem;
    margin-bottom: var(--space-xs);
}
.tumor-card-hub .tc-name {
    font-family: var(--font-display);
    font-size: 0.95rem;
    font-weight: 700;
    color: var(--text-primary);
    line-height: 1.3;
}
.tumor-card-hub .tc-count {
    font-family: var(--font-mono);
    font-size: 0.78rem;
    color: var(--accent-soft);
    font-weight: 600;
}
.tumor-card-hub .tc-tag {
    font-size: 0.68rem;
    color: var(--text-muted);
    text-transform: uppercase;
    letter-spacing: 0.08em;
}

/* ═══ RESPONSIVE — Tumor Pages ═══ */
@media (max-width: 900px) {
    .tumor-hero-inner { grid-template-columns: 1fr; }
    .tumor-icon-ring { width: 100px; height: 100px; font-size: 3rem; margin: 0 auto; }
    .tumor-stats { grid-template-columns: repeat(2, 1fr); }
    .hero-stats { grid-template-columns: repeat(2, 1fr); }
}
@media (max-width: 640px) {
    .tumor-hero h1 { font-size: 1.8rem; }
    .tumor-stats { grid-template-columns: 1fr 1fr; gap: var(--space-md); }
    .hero-stats { grid-template-columns: 1fr 1fr; gap: var(--space-md); }
    .tumor-stat-value { font-size: 1.5rem; }
    .stat-value, .stat-number { font-size: 1.5rem; }
    .tumor-grid-hub { grid-template-columns: repeat(2, 1fr); }
    .filter-row { flex-direction: column; }
}

/* ═══ Nav scroll offset fix ═══ */
[id^="nav-"], [id="faq-section"] {
    scroll-margin-top: 70px;
}

/* ═══ Related Cancer Types Section ═══ */
.related-section {
    max-width: 1400px;
    margin: var(--space-2xl) auto;
    padding: 0 2rem;
}
.related-inner {
    background: var(--bg-card);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-lg);
    padding: var(--space-xl);
    box-shadow: var(--shadow-card);
}
.related-inner h2 {
    font-family: var(--font-display);
    font-size: 1.5rem;
    color: var(--text-primary);
    text-align: center;
    margin-bottom: var(--space-xs);
}
.related-subtitle {
    text-align: center;
    color: var(--text-muted);
    font-size: 0.9rem;
    margin-bottom: var(--space-lg);
}
.related-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: var(--space-md);
}
.related-link {
    display: block;
    padding: 0.875rem 1.25rem;
    background: var(--bg-elevated);
    border: 1px solid var(--border-subtle);
    border-radius: var(--radius-sm);
    color: var(--accent-soft);
    text-decoration: none;
    font-weight: 600;
    font-size: 0.9rem;
    transition: var(--transition);
}
.related-link:hover {
    background: var(--accent-glow);
    border-color: var(--border-glow);
    color: var(--cyan);
    transform: translateX(4px);
}
.related-cta {
    text-align: center;
    margin-top: var(--space-lg);
}
.related-cta a {
    color: var(--accent-soft);
    font-weight: 600;
    text-decoration: none;
    transition: var(--transition-fast);
}
.related-cta a:hover { color: var(--cyan); }

/* ═══ Reading Progress Bar ═══ */
#reading-progress {
    position: fixed;
    top: 0;
    left: 0;
    height: 3px;
    background: linear-gradient(90deg, var(--accent), var(--cyan), var(--emerald));
    z-index: 10000;
    transition: width 0.1s linear;
    width: 0;
}